the efficacy of oral erythromycin in enhancement of milk tolerance in premature infants: a randomized clinical trial

Authors

a. madani neonatology section, department of pediatrics, shiraz university of medical sciences, shiraz, iran.

n. pishva neonatology section, department of pediatrics, shiraz university of medical sciences, shiraz, iran.

sh. pourarian neonatology section, department of pediatrics, shiraz university of medical sciences, shiraz, iran.

m. zarkesh neonatology section, department of pediatrics, shiraz university of medical sciences, shiraz, iran.

abstract

background:  a great number of premature neonates do not tolerate sufficient milk during the early neonatal period.   objective: to evaluate the effect of oral erythromycin on enhancement of feeding tolerance in preterm newborns.   methods: sixty preterm neonates intolerant to milk of >75 ml/kg/day during 5 days after the start of feedings, were randomized into a treatment and a control groups.  oral erythromycin (12.5 mg/kg/dose) was given to the treatment group for a maximum of 10 days, or until full enteral feeding (150 ml/kg/day) was tolerated.   results: oral erythromycin enhanced feeding tolerance in premature neonates of ≥ 32 wks of gestation (p<0.032) with no adverse effects and led to a shorter hospital stay (p<0.003) as compared to the control group.   conclusion:   oral erythromycin is an effective drug for alleviating feeding intolerance in preterms.

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Journal title:
iranian journal of medical sciences

جلد ۲۹، شماره ۱، صفحات ۱-۰

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